Clinical Evidence - Methemoglobin (SpMet^®)

Featured Clinical Studies:

Methemoglobin and nitric oxide therapy in Ugandan children hospitalized for febrile illness: results from a prospective cohort study and randomized double-blind placebo-controlled trial. Conroy AL et al. BMC Pediatr. 2016 Nov 4;16(1):177
Pulse-Oximetric Measurement of Prilocaine-Induced Methemoglobinemia in Regional Anesthesia. Soeding P., Deppe M., Gehring H. Anesth Analg. 2010 Oct;111(4):1065-8.
Severe Methemoglobinemia Detected by Pulse Oximetry. Annabi E.H., Barker S,J. Anesth Analg. 2009;108:898–9.
Improved Accuracy of Methemoglobin Detection by Pulse CO-Oximetry during Hypoxia. Feiner J.R., Bickler P.E. Anesth Analg. 2010 Nov;111(5):1160-7.
The Measurement of Carboxyhemoglobin and Methemoglobin using a Non-Invasive Pulse COOximeter. Zaouter C., Zavorsky G.S. Respir Physiol Neurobiol. 2012 May 15;182(2-3):88-92.
Non-Invasive Measurements of Carboxyhemoglobin and Methemoglobin in Children with Sickle Cell Disease. Caboot J.B., Jawad A.F., McDonough J.M., Bowdre C.Y., Arens R., Marcus C.L., Mason T.B., Smith-Whitley K., Ohene-Frempong K., Allen J.L. Pediatr Pulmonol. 2012 Aug;47(8):808-15.
Measurement of Carboxyhemoglobin and Methemoglobin by Pulse Oximetry: A Human Volunteer Study. Barker S.J., Curry J., Redford D., Morgan S. Anesthesiology. 2006 Nov;105(5):892-7.

Full Citation List of All Available Studies:*

Methemoglobin and nitric oxide therapy in Ugandan children hospitalized for febrile illness: results from a prospective cohort study and randomized double-blind placebo-controlled trial. Conroy AL et al. BMC Pediatr. 2016 Nov 4;16(1):177
Pulse CO-Oximetry - Clinical Impact in the Emergency Department Exadaktylos A, Braun CT, Ziaka M, Trends in Anaesthesia and Critical Care (2014), doi: 10.1016 j.tacc.2014.07.002.
Methemoglobinemia Precipitated by Benzocaine Used During Intubation Afzal A, Collazo R, Fenves AZ, Schwartz J. Proc (Bayl Univ Med Cent). 2014 Apr;27(2):133-5.
Methemoglobin Levels in Generally Anesthetized Pediatric Dental Patients Receiving Prilocaine versus Lidocaine. Gutenberg L.L., Chen J.W., Trapp L.. Anesth Prog. 2013 Fall;60(3):99-108.
Non-Invasive Measurements of Carboxyhemoglobin and Methemoglobin in Children with Sickle Cell Disease. Caboot J.B., Jawad A.F., McDonough J.M., Bowdre C.Y., Arens R., Marcus C.L., Mason T.B., Smith-Whitley K., Ohene-Frempong K., Allen J.L. Pediatr Pulmonol. 2012 Aug;47(8):808-15.
The Measurement of Carboxyhemoglobin and Methemoglobin using a Non-Invasive Pulse COOximeter. Zaouter C., Zavorsky G.S. Respir Physiol Neurobiol. 2012 May 15;182(2-3):88-92.
The current status of continuous noninvasive measurement of total, carboxy, and methemoglobin concentration. Shamir M.Y., Avramovich A., Smaka T. Anesth Analg. 2012 May;114(5):972-8..
The Usefulness of Noninvasive MetHb Monitoring at HBOT Department (Pulse CO-Oximetry Masimo Rainbow SET RAD-57). Nakashima M., Tsutsumi Y., Ifuku T., Tachibana H., Tamehiro K. , Taki K., Shima H. Crit Care Med. 2010 Vol. 38, No. 12 (Suppl.).
Improved Accuracy of Methemoglobin Detection by Pulse CO-Oximetry during Hypoxia. Feiner J.R., Bickler P.E. Anesth Analg. 2010 Nov;111(5):1160-7.
Pulse Oximeter Methemoglobin Measurements in Patients with Tumescent Anaesthesia and Prilocaine. Boye S., Opp A., Klose A., Schmeller W., Gehring H. Proceedings of the 2010 Annual Meeting of the American Society of Anesthesiologists. A886.
Pulse-Oximetric Measurement of Prilocaine-Induced Methemoglobinemia in Regional Anesthesia. Soeding P., Deppe M., Gehring H. Anesth Analg. 2010 Oct;111(4):1065-8.
Accuracy of Methemoglobin Detection by Pulse CO-Oximetry during Hypoxia. Feiner J.R., Bickler P.E., Mannheimer P.D. Anesth Analg. 2010 Jul;111(1):143-8.
Severe Methemoglobinemia Detected by Pulse Oximetry. Annabi E.H., Barker S,J. Anesth Analg. 2009;108:898–9.
The Prevalence of Methemoglobin in HIV Infected Patients on Chronic Dapsone Therapy for Prophylaxis of Pneumocystis jirovecii Infection. O'Neal H.R. Crit Care Med. 2008 Vol. 36(12) (Suppl):682.
The Measurement of Dyshemoglobins and Total Hemoglobin by Pulse Oximetry. Barker S.J., Badal J.J. Curr Opin Anaesthesiol. 2008 Dec;21(6):805-10.
Do Pulse CO-Oximeter Measures of SpMet and SpO2 Correlate with Blood Gas CO-Oximetry in Neonates? Goldstein M.R., Saesim D., Macknet M., Allard M., Peverini R. Anesthesiology. 2008; 109 A1218.
Benzocaine Induced Methhemoglobin after T.E.E Macknet M.R., Kimball-Jones P.L. Applegate R.L., Martin R.D., Allard M.W. Respir Care. 2007;52(11).
Rad-57 Rainbow CO-Oximeter in Detecting Methemoglobin during Upper GI Endoscopy - A Case Report Padakandla U.B. Anesthesiology. 2007; 107: A1543.
Measurement of Carboxyhemoglobin and Methemoglobin by Pulse Oximetry: A Human Volunteer Study. Barker S.J., Curry J., Redford D., Morgan S. Anesthesiology. 2006 Nov;105(5):892-7.
Noninvasive Monitoring for Methemoglobinemia after Topical Application of Benzocaine during Upper Endoscopy and Trans-esophageal Echocardiography Schembre D., Ayub K., Gibbons E., Simmons S., Hampson N. Gastroenterol. 126(4) April 2004 Supplement 2. W1284.

* Duplicate abstracts or publications are excluded

indicates an abstract presented at a congress

indicates peer-reviewed journal article

indicates an Open Access article

Masimo devices with SpMet monitoring are not intended to replace laboratory blood testing. Blood samples should be analyzed by laboratory instruments prior to clinical decision making.

PLCO-000762/PLMM-10366A-0217