Clinical Applications

Masimo PVI has been shown to help clinicians assess fluid responsiveness as reliably as new invasive parameters, and better than traditional invasive parameters.1,2

This observational study evaluated 25 surgical patients before and after volume expansion, with fluid responders (sensitivity) defined as a cardiac index increase of >15% and fluid non-responders (specificity) defined as a cardiac index increase of <15%.

This study has shown PVI to be an effective alternative indicator for accurate, noninvasive, and continuous fluid responsiveness in mechanically ventilated patients undergoing major surgery.

Aiding Clinicians in Reducing Patient Risk

A recent randomized trial showed that compared to standard care without PVI, clinicians using PVI PEEP were able to improve fluid management and as a result, reduce patient risk.3 By helping clinicians maintain appropriate fluid and oxygen levels in the blood, important organs may be protected.

This randomized study of 82 abdominal surgery patients found that PVI-based, goal-directed fluid management reduced the volume of intraoperative fluid infused and reduced intraoperative and postoperative lactate levels.3

All available PVI studies are listed here.


  • 1 Cannesson M. et al. Br J Anaesth. 2008;101(2):200-6.
  • 2 Zimmermann M et al. Eur J Anaesthesiol. 2010 Jun;27(6):555-61.
  • 3 Desebbe O., Boucau C., Farhat F., Bastien O., Lehot J.J., Cannesson M. Anesth Analg. 2010 Mar 1;110(3):792-8.
  • 4 Forget P. et al. Anesth Analg. 2010;111(4):910-4.